Xiang Y, Naro F, Zoudilova M, Jin SL, Conti M, Kobilka B. Phosphodiesterase 4D is required for {beta}2 adrenoceptor subtype-specific signaling in cardiac myocytes.
Proc Natl Acad Sci U S A. 2005 Jan 11.

Lathi R, Hess A, Tulac S, Nayak N, Conti M, Giudice L. Dose-Dependent Insulin Regulation of IGFBP-1 in Human Endometrial Stromal Cells is Mediated by Distinct Signaling Pathways.
J Clin Endocrinol Metab. 2004 Dec 21.

Richter W, Conti M. The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases.
J Biol Chem. 2004 Jul 16;279(29):30338-48. Epub 2004 May 06.

Park JY, Su YQ, Ariga M, Law E, Jin SL, Conti M. EGF-like growth factors as mediators of LH action in the ovulatory follicle.
Science. 2004 Jan 30;303(5658):682-4. Epub 2004 Jan 15.

Xie F, Conti M. Expression of the soluble adenylyl cyclase during rat spermatogenesis: evidence for cytoplasmic sites of cAMP production in germ cells.
Dev Biol. 2004 Jan 1;265(1):196-206.

Barnes AP, Livera G, Huang P, Sun C, O'neal WK, Conti M, Stutts MJ, Milgram SL. Phosphodiesterase 4D Forms a cAMP diffusion barrier at the apical membrane of the airway epithelium.
J Biol Chem. 2004 Dec 15.

Ariga M, Neitzert B, Nakae S, Mottin G, Bertrand C, Pruniaux MP, Jin SL, Conti M. Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.
J Immunol. 2004 Dec 15;173(12):7531-8.

Nedachi T, Conti M. Potential role of protein tyrosine phosphatase nonreceptor type 13 in the control of oocyte meiotic maturation.
Development. 2004 Oct;131(20):4987-98. Epub 2004 Sep 15.

Conti M. A view into the catalytic pocket of cyclic nucleotide phosphodiesterases.
Nat Struct Mol Biol. 2004 Sep;11(9):809-10.

Mehats C, Jin SL, Wahlstrom J, Law E, Umetsu DT, Conti M. PDE4D plays a critical role in the control of airway smooth muscle contraction.
FASEB J. 2003 Oct;17(13):1831-41.

Jaiswal BS, Conti M. Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa.
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10676-81. Epub 2003 Sep 04.

Horner K, Livera G, Hinckley M, Trinh K, Storm D, Conti M. Rodent oocytes express an active adenylyl cyclase required for meiotic arrest.
Dev Biol. 2003 Jun 15;258(2):385-96.

Park JY, Richard F, Chun SY, Park JH, Law E, Horner K, Jin SL, Conti M. Phosphodiesterase regulation is critical for the differentiation and pattern of gene expression in granulosa cells of the ovarian follicle.
Mol Endocrinol. 2003 Jun;17(6):1117-30. Epub 2003 Mar 20.

Conti M, Richter W, Mehats C, Livera G, Park JY, Jin C. Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.
J Biol Chem. 2003 Feb 21;278(8):5493-6. Epub 2002 Dec 18. Review. No abstract available.
PMID: 12493749 [PubMed - indexed for MEDLINE]

Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA. Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
Biochem J. 2003 Jan 15;369(Pt 2):227-38.

Richter W, Conti M. Dimerization of the type 4 cAMP-specific phosphodiesterases is mediated by the upstream conserved regions (UCRs).
J Biol Chem. 2002 Oct 25;277(43):40212-21. Epub 2002 Aug 12.

Jin SL, Conti M. Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses.
Proc Natl Acad Sci U S A. 2002 May 28;99(11):7628-33.

Conti M. Specificity of the cyclic adenosine 3',5'-monophosphate signal in granulosa cell function.
Biol Reprod. 2002 Dec;67(6):1653-61. Review.

Regulation of cAMP-specific phosphodiesterases type 4B and 4D (PDE4) splice variants by cAMP signaling in primary cortical neurons. D'Sa C, Tolbert LM, Conti M, Duman RS J Neurochem 2002 81(4):745-57

Role of cyclic nucleotide signaling in oocyte maturation. Conti M, Andersen CB, Richard F, Mehats C, Chun SY, Horner K, Jin C, Tsafriri A Mol Cell Endocrinol 2002 187(1-2):153-9

Phosphodiesterase 3 inhibitors selectively block the spontaneous resumption of meiosis by macaque oocytes in vitro. Jensen JT, Schwinof KM, Zelinski-Wooten MB, Conti M, DePaolo LV, Stouffer RL Hum Reprod 2002 17(8):2079-2084

Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling. Mehats C, Andersen CB, Filopanti M, Jin SL, Conti M. Trends Endocrinol Metab 2002 13(1):29-35

Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1. Firestein R, Nagy PL, Daly M, Huie P, Conti M, Cleary ML J Clin Invest 2002 109(9):1165-72

Cloning and characterization of cyclic guanosine monophosphate-inhibited phosphodiesterase PDE3A expressed in mouse oocyte. Shitsukawa K, Andersen C, Richard F, Horner AK, Wiersma A, van Duin M, Conti M Biol Reprod 2001 65:188-96

Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase. Jaiswal BS, Conti M J Biol Chem 2001 276:31698-31708

Role of phosphodiesterase type 3A in rat oocyte maturation. Richard F, Tsafriri A, Conti M Biol Reprod 2001 65:1444-51

Myomegalin: a novel scaffold protein of the Golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase. Verde I, Pahlke G, Salanova M, Zhang G, Wang S, Onuffer J, Jin S-L C, and Conti M J Biol Chem 2001 276:11189-11198

Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area. Tasken KA, Collas P, Kemmner WA, Witczak O, Conti M, Tasken K J Biol Chem 2001 276:21999-22002

Short-term feedback regulation of cAMP in FRTL-5 thyroid cells: role of PDE4D3 phosphodiesterase activation. Oki N, Takahashi S, Hidaka H and Conti M J Biol Chem 2000 275:10831-10837

Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D. Hansen G, Jin S-L C, Umetsu DT, Conti M Proc Natl Acad Sci U S A 2000 97:6751-6756

The cAMP-specific phosphodiesterase PDE4D3 is regulated by phosphatidic acid binding consequences for cAMP signaling pathway and characterization of a phosphatidic acid binding site. Grange M, Sette C, Cuomo M, Conti M, Lagarde M, Prigent AF, Nemoz G J Biol Chem 2000 275:33379-33387

Induction of specific phosphodiesterase isoforms by constitutive activation of the cAMP pathway in autonomous thyroid adenomas. Persani L, Lania A, Alberti L, Ronoli R, Mantovani G, Filetti S, Spada A, Conti M J Clin Endocrinol Metab 2000 85:2872-2878

Specific expression of soluble adenylyl cyclase in male germ cells. Sinclair M, Wang X-Y, Mattia M, Conti M, Buck J, Wolgemuth D, Levin L Mol Reprod Dev 2000 56:6-11

Surgically-induced cryptorchidism-related degenerative changes in spermatogonia are associated with loss of cyclic AMP-phosphodiesterases type 4 (PDE4) in abdominal testis of rat. Farooqui SM, Al-Bagdadi F, Houslay MD, Bolger GD, Rhett S, Specian RD, Conti M, O'Donnell JM Biol Reprod 2000 (In press)

Chronic antidepressant administration increases the expression of cAMP-specific phosphodiesterase 4A and 4B isoforms. Takahashi M, Terwilliger R, Lane C, Mezes PS, Conti M and Duman RS J Neurosci 1999 19:610-618

Type 4 cAMP-specific phosphodiesterases are expressed in discrete subcellular compartments during rat spermiogenesis. Salanova M, Chun S-Y, Xu X, Iona S, Puri C, Eddy E, Stefanini M and Conti M Endocrinology 1999 140: 2297-2306

Activation of PDE4D3 by phosphorylation: identification and function of an inhibitory domain. Lim J, Pahlke G and Conti M J Biol Chem 1999 274:19677-19685

Involvement of type 4 cylcic AMP phosphodiesterase in the miogenic differentiation of L6 cells. Naro F, Sette C, Vicini E, Grange M, Conti M, Adamo S and Nemoz G Mol Biol Cell 1999 12:4355-4367

Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D deficient mice. Jin S-L C, Richard F, Kuo W-P, D'Ercole AJ, Conti M Proc Natl Acad Sci U S A 1999 96:11998-20003

Activation of the mitogen activated protein kinase ERK1 during meiotic progression of mouse pachytene spermatocytes. Sette C, Barchi M, Bianchini A, Conti M, Rossi P, Geremia R J Biol Chem 1999 274:33571-33579

The molecular Biology of Cyclic Nucleotide Phosphodiesterases
Conti M., Jin S-LC., Prog Nucleic Acid Res Mol Biol 1999 63:1 - 38

Characterization of the rolipram-sensitive, cAMP-specific phosphodiesterases: identification and differential expression of immunologically distinct forms in the rat brain. Iona S, Cuomo M, Bushnik T, Naro F, Sette C, Hess M, Shelton ER and Conti M Mol Pharmacol 1998 53:23-32

The olfactory adenylyl cyclase III is expressed in rat germ cells during spermiogenesis. Gautier-Courteille C, Salanova M and Conti M Endocrinology 1998 139:2588-2599

Enhancement of motility and acrosome reaction in human spermatozoa: differential activation by type-specific phosphodiesterase inhibitors. Fisch JD, Behr B and Conti M Hum Reprod 1998 13:1248-1254

Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents. Weirsma A, Hirsch B, Tsafriri A, Hanssen RGJM, Van de Kant M, Kloosterboer HJ, Conti M and Hsueh AJW J Clin Invest 1998 102:532-537

Subcellular localization of the rolipram-sensitive, cAMP-specific phosphodiesterase: differential targeting of the splicing variants derived from the PDE4D gene. Jin S-L, Bushnik T, Lan L and Conti M J Biol Chem 1998 273:19672-19678

The protein kinase Akt/PKB induces the resumption of meiosis in Xenopus oocytes. Andersen CB, Roth RA and Conti M J Biol Chem 1998 274:18705-18708

Role of phosphodiesterases in the regulation of gonadotropin releasing hormone secretion in GT1 cells. Sakakibara H, Conti M and Weiner RI Neuroendocrinology 1998 68:365-373

Characterization of an intronic promoter of a cyclic adenosine 3',5'-monophosphate (cAMP)-specific phosphodiesterase gene that confers hormone and cAMP inducibility. Vicini E and Conti M Mol Endocrinol 1997 11:839-850

Selective activation of rolipram-sensitive, cAMP-specific phosphodiesterase isoforms by phosphatidic acid. Nemoz G, Sette C and Conti M Mol Pharmacol 1997 51:242-249

Activation of phosphodiesterase IV during desensitization of the A2A-adenosine receptor-mediated cAMP response in rat pheochromocytoma (PC12) cells. Chang YH, Conti M, Lee YC, Lai HL, Ching YH and Chern Y J Neurochem 1997 69:1300-1309

Selective stimulation of a cAMP-specific phosphodiesterase (PDE4A5) isoform by phosphatidic-acid molecular-species endogenously formed in rat thymocytes. Elbawab S, Macovschi O, Sette C, Conti M, Lagarde M, Nemoz G and Prigent AF Eur J Biochem 1997 247:1151-1157

Co-expression of defective luteinizing hormone receptor fragments partially reconstitutes ligand-induced signal generation. Osuga Y, Hayashi M, Kudo M, Conti M, Kobilka B and Hsueh AJW J Biol Chem 1997 272:25006-25012

Noradrenergic activity differentially regulates the expression of rolipram-sensitive, high-affinity cyclic-AMP phosphodiesterase (PDE4) in rat-brain. Ye Y, Conti M, Houslay MD, Farooqui SM, Chen M and O'Donnell JM J Neurochem 1997 69:2397-2404